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All answers having "Significant" as clue:

3 Character Answers:

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KEY



5 Character Answers:

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GREAT

MAJOR

MEATY

OTHER



6 Character Answers:

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OFNOTE



7 Character Answers:

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FATEFUL

NOTABLE

POINTED

POLEMIC

SIZABLE

TELLING



8 Character Answers:

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EVENTFUL

HISTORIC

PREGNANT



9 Character Answers:

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IMPORTANT



10 Character Answers:

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MEANINGFUL



12 Character Answers:

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CONSIDERABLE



13 Character Answers:

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OFCONSEQUENCE