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Drug that's a downer
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OPIATE
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Inhale, so to speak
Eritrea's locale in Africa
Eminem hit whose title became a neologism for "fan"
"Animal skin," in Aleut
Features of the sci-fi planet Arrakis
"Totes adorbs!"
Country represented by the Black Star of Africa
Handful on the farm
Sports great who said "If the world were perfect, it wouldn't be"
Org. with a commissioner
People always getting favorable news coverage
Ralph who wrote the novel "Juneteenth"
Pokémon tagline
Some digital assistants, informally
Target of the 1890 Sherman Act
God who wears the belt Megingjörd
Chilling, maybe
Like wetlands, typically
Freedom of expression?
Not pay as one goes
How Mario introduces himself in video games
Begin listening to a podcast, say
Tribal spiritualist
With 48-Across, cousin of sleet
Home of the Cotahuasi Canyon, which is more than two miles deep
Attire often used in filming C.G.I. scenes, informally
"Hot-diggity" or "Cool it"
"How you ___?" ("Friends" catchphrase)
Show again, as a historical event
"About damn time!"
Item that might be on a list
Many an M.B.A.'s undergrad major, informally
Item not found much in cars nowadays
"Who ___?" (informal question)
It's a short walk from home
Site with a "Craft Supplies & Tools" category
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