To cause (a person or animal) to become lame. Example: 1877, Anna Sewell, Black Beauty: And if you don't want to lame your horse you must look sharp and get them [stones stuck in hooves] out quickly.
Unable to walk properly because of a problem with one's feet or legs.
Moving with pain or difficulty on account of injury, defect or temporary obstruction of a function. Example: a lame leg, arm or muscle