Word: safest
Not in danger; out of harm's reach. Example: You’ll be safe here.
Free from risk. Example: It’s safe to eat this.
Providing protection from danger; providing shelter. Example: We have to find a safe spot, where we can hide out until this is over.
When a batter successfully reaches first base, or when a baserunner successfully advances to the next base or returns to the base he last occupied; not out. Example: The pitcher attempted to pick off the runner at first, but he was safe.
Properly secured. Example: The documents are safe.
(used after a noun, often forming a compound) Not susceptible to a specified source of harm. Example: dishwasher-safe
Great, cool, awesome, respectable; a term of approbation, often as interjection.
Lenient, usually describing a teacher that is easy-going.
Reliable; trusty.
Cautious.
Of a programming language, type-safe or more generally offering well-defined behavior despite programming errors.
You can find a list of possible crossword clues for SAFEST below.