Word: downer
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A negative drug trip. Example: Normally those pills give me a boost, but last night they gave me a downer.
A drug that has depressant qualities.
Something or someone disagreeable, dispiriting or depressing; a killjoy.
A livestock animal that has collapsed.
A form of industrial action in which workers down tools and refuse to work.
You can find a list of possible crossword clues for DOWNER below.