Word: derails
To cause to come off the tracks. Example: The train was destroyed when it was derailed by the penny.
To come off the tracks.
To deviate from the previous course or direction. Example: The conversation derailed once James brought up politics.
To cause to deviate from a set course or direction; derange. Example: The protesting students derailed the professor's lecture.
You can find a list of possible crossword clues for DERAILS below.